![]() The medication package insert includes information about which devices were used in the clinical trials. Yet even conventional devices are often tested with a drug. These drug-specific nebulizers use advanced technologies to create more efficient delivery than that of conventional devices. PARI also offers the eFlow to pharmaceutical companies seeking a customizable drug delivery platform. Novartis’ TOBI (tobramycin), which treats lung infections in cystic fibrosis patients, is approved for use by the FDA only with PARI’s LC Plus Reusable Nebulizer. For example, Ventavis, a prostacyclin therapy from Actelion Pharmaceuticals US Inc, San Francisco, is approved for use only with the I-neb AAD System from Respironics. In some instances, a drug has been approved for use only with a specific nebulizer, making the decision easy. The patient also influences the physician’s selection of a specific nebulizer, although it may not be the biggest factor, as physicians must consider the drug delivered and the setting for delivery. This will often impact the physician’s decision to prescribe a nebulizer over other options. Their small size makes them more convenient, but they are also more complex, requiring hand and breath coordination that is sometimes beyond the capabilities of the patient (particularly pediatric and geriatric patients). Nebulizers are one of three methods available for the delivery of inhalation treatments the other two are metered dose inhalers (MDI) and dry powder inhalers (DPI), both handheld devices. Cambridge, BS, RRT, director of clinical development at PARI Respiratory Equipment Inc in Midlothian, Va. ![]() “There are drugs in development that will be delivered through the lung … for systemic delivery for treatment of conditions such as migraines, pain management, cancer treatment, and hormone replacement, to name a few,” says Lisa A. Inhaled insulin is a well-known example, although it is delivered using a dry powder inhaler. There are drugs in development, however, that use the lungs as a delivery path to somewhere else in the body. The lungs are often the quickest way to deliver treatments for conditions such as asthma, COPD (chronic obstructive pulmonary disease), cystic fibrosis, pneumonia, and pulmonary hypertension. Pulmonary ailments are, by far, the most common diagnoses of patients prescribed nebulizers. Gordon, director of marketing for Respironics Respiratory Drug Delivery in Parsippany, NJ. It’s their great advantage compared to other devices, which might be smaller or more complex,” says Tim H. The whole point of nebulizers is they are the simple, easy way to get respiratory drugs in.
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